Hydrochloric Acid → 1-(3'-Formylamino-phenyl)-2-amino-propane hydrochloride
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]([NH2:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.[ClH:12].[CH3:13][OH:14]>>[ClH:12].[CH:13]([NH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH:9]([NH2:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1)=[O:14]Participants
4
Procedure
255 gm of 1-(3'-amino-phenyl)-2-amino-propane were dissolved in methanol, and the solution was acidified with ethereal hydrochloric acid. The monohydrochloride thus obtained was refluxed for 2 hours in 225 ml of formic acid, and the reaction mixture was then evaporated in a water aspirator vacuum, leaving a yellow oil which solidified upon being digested with ether. The solidified product was recrystallized from ethanol by addition of ether, yielding the compound of the formula ##STR15## which had a melting point of 150°-153° C.
Sources & evidence
- ORD record
- ord-e8d47a72ce1847918b8c9754d0c6f5c5
- Source dataset
- uspto-grants-1977_03
- Patent number
- US04015011
Reaction notes
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