HCID 59715735, compound → HCID 59715643, compound

HRID 597784Notes

Reaction equation

HRID 597784 reaction equation
[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]([CH2:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:20]#[CH:21])[CH:18]=3)[CH:13]=[CH:12][N:11]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]>O1CCCC1.[C].[Pd]>[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]([CH2:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([CH2:20][CH3:21])[CH:18]=3)[CH:13]=[CH:12][N:11]=2)=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 59715735HCID 59715735, compound

Product 1

HCID 59715643HCID 59715643, compoundYield 10.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Palladium-carbon (10%, 5.0 mg) was added to a solution of the compound of Example B158 (2.0 mg) in tetrahydrofuran (2.0 ml), and the mixture was stirred at room temperature under nitrogen atmosphere (1 atm) for 1 hour. The catalyst was removed by filtration, and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (0.21 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-9961c8484dcc4be4b00da7c8305d5882
Source dataset
uspto-grants-2011_03
Patent number
US07897387B2

Reaction notes

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