Methyl iodide → HCID 59715700, compound

HRID 597788Notes

Reaction equation

HRID 597788 reaction equation
[C:1](=[O:4])([O-])[O-].[K+].[K+].CI.[Br:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](=[O:20])[CH2:17][CH2:18][CH3:19])=[C:12](O)[CH:11]=1>CC(C)=O>[Br:9][C:10]1[CH:11]=[CH:12][C:13]([C:16](=[O:20])[CH2:17][CH2:18][CH3:19])=[C:14]([O:4][CH3:1])[CH:15]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 59715687HCID 59715687, compound

Product 1

HCID 59715700HCID 59715700, compoundYield 67.7%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Potassium carbonate (9.07 g) and methyl iodide (3.92 ml) were added to a solution of the compound of Example B220 (13.30 g) in acetone (75 ml), and this reaction mixture was stirred while heating under reflux for 4 hours. The reaction mixture was filtered through celite, ether was added to remove insoluble material by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (9.52 g).

Workup

  1. temperaturewhile heating
  2. temperatureunder reflux for 4 hours
  3. filtrationThe reaction mixture was filtered through celite, ether
  4. additionwas added
  5. customto remove insoluble material
  6. filtrationby filtration
  7. concentrationthe filtrate was concentrated under reduced pressure
  8. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-278bfaeef23848fbaf87b85f11597d2f
Source dataset
uspto-grants-2011_03
Patent number
US07897387B2

Reaction notes

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