Trifluoroacetic acid → HCID 11257170, compound

HRID 597799Notes

Reaction equation

HRID 597799 reaction equation
FC(F)(F)C(O)=O.C(OC(=O)[NH:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([S:22](=[O:38])(=[O:37])[NH:23][C:24](=[O:36])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[CH:18][CH:17]=1)(C)(C)C>ClCCl>[NH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH:23][C:24](=[O:36])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])(=[O:37])=[O:38])=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58871554HCID 58871554, compound

Product 1

HCID 11257170HCID 11257170, compoundYield 128.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (25 ml) was at room temperature added to a solution of (4-(dodecanoylsulfamoyl)benzyl)carbamic acid tert-butyl ester (170 mg, 0.40 mmol) in dichloromethane (25 ml). The reaction mixture was stirred for 1 h at room temperature. The solvents were removed in vacuo. The residue was dissolved in dichloromethane (40 ml) and the solvent was removed in vacuo. The latter procedure was repeated once to give 0.19 g of the trifluoroacetic salt of 4-aminomethyl-N-(dodecanoyl)benzenesulfonamide.

Workup

  1. customwas at room temperature
  2. customThe solvents were removed in vacuo
  3. dissolutionThe residue was dissolved in dichloromethane (40 ml)
  4. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-459b6b9368da4281ba4ce6419e500a84
Source dataset
uspto-grants-2011_03
Patent number
US07897560B2

Reaction notes

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