反应详情

1.40 g of 3-(2-(1-benzothiophene-4-yl)ethoxy)-1-propanol was dissolved in 7.0 ml of methylene chloride. Thereafter, 1.10 ml of thionyl chloride and 0.05 ml of N,N-dimethylformamide were added to the obtained solution, and the obtained mixture was then heated to reflux for 5 hours. Subsequently, the solvent was distilled away under a reduced pressure. The residue was purified by column chromatography (eluent; hexane:ethyl acetate=20:1), so as to obtain 1.43 g of a yellow oil product, 4-(2-(3-chloropropoxy)ethyl)-1-benzothiophene.

1. temperaturethe obtained mixture was then heated
2. temperatureto reflux for 5 hours
3. distillationSubsequently, the solvent was distilled away under a reduced pressure
4. customThe residue was purified by column chromatography (eluent; hexane:ethyl acetate=20:1)