HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 2-(((1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)(4-chlorophenethyl)amino)-methyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 121410305 | HCID 121410305 | — |
| Reactant | N-cyanopiperazine-1-carbimidothioate | HCID 131737066 | — |
| Product | Methyl 2-(((1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)(4-chlorophenethyl)amino)-methyl)benzoate | HCID 178497630 | — |
Reaction Steps
Methyl 2-(((4-chlorophenethyl)(piperidin-4-yl)amino)methyl)benzoate hydrochloride obtained in Step 2 was reacted with K2CO3 and S,S′-dimethyl-N-cyano-dithioiminocarbonate, followed by the cyclization of the intermediate (N-cyanopiperazine-1-carbimidothioate) with hydrazine monohydrate in a manner described in Procedure 3. ESI MS for C24H29ClN6O2: calculated 468.99. found 469.4/471.4 (M+1), 467.3/469.3 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440953B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-ac3dfa39f10e4c508c4d38248688f596 |
| Source note | uspto-grants-2016_09 |