反应详情

Methyl 2-(((4-chlorophenethyl)(piperidin-4-yl)amino)methyl)benzoate hydrochloride obtained in Step 2 was reacted with K2CO3 and S,S′-dimethyl-N-cyano-dithioiminocarbonate, followed by the cyclization of the intermediate (N-cyanopiperazine-1-carbimidothioate) with hydrazine monohydrate in a manner described in Procedure 3. ESI MS for C24H29ClN6O2: calculated 468.99. found 469.4/471.4 (M+1), 467.3/469.3 (M−1).