反应详情

In a 2 L round bottom flask combine 3-chloro-6-pyridazinamine (43.2 g, 333.5 mmol), toluene (500 mL), and N,N-dimethylacetamide dimethyl acetal (67.8 mL, 1.25 equiv.). Attach a reflux condenser then heat to reflux for 2 h. Let cool to RT. Concentrate in vacuo. Triturate the crude material with hexanes and filter to isolate the title compound (60.4 g, 91%) as a light tan solid. MS=199.0 (M+1).

1. customIn a 2 L round bottom flask combine
2. temperaturethen heat
3. temperatureto reflux for 2 h
4. concentrationConcentrate in vacuo
5. customTriturate the crude material with hexanes
6. filtrationfilter