HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Allyl 4-((2-aminoethyl)(4-chlorophenethyl)amino)piperidine-1-carboxylate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 121410342 | HCID 121410342 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Allyl 4-((2-aminoethyl)(4-chlorophenethyl)amino)piperidine-1-carboxylate hydrochloride | HCID 121410349 | — |
Reaction Steps
1-Allyloxycarbonyl-N-[2-(tert-butoxycarbonylamino)ethyl]-N-[2-(4-chlorophenyl)ethyl]-piperidin-4-amine obtained in Step 1 was subjected to the deprotection reaction as described in Procedure 2 (4 N HCl in EtOAc). The crude product that was obtained in this step was used in the synthesis of Examples 8-13 without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440953B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-2bc9a29bd965412ebae204671b6815e0 |
| Source note | uspto-grants-2016_09 |