Hydrochloric Acid → Allyl 4-((2-aminoethyl)(4-chlorophenethyl)amino)piperidine-1-carboxylate hydrochloride

HRID 59786Notes

Reaction equation

HRID 59786 reaction equation
[CH2:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([N:13]([CH2:23][CH2:24][NH:25]C(OC(C)(C)C)=O)[CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[CH2:9][CH2:8]1)=[O:6])[CH:2]=[CH2:3].Cl>CCOC(C)=O>[ClH:22].[NH2:25][CH2:24][CH2:23][N:13]([CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)[CH:10]1[CH2:9][CH2:8][N:7]([C:5]([O:4][CH2:1][CH:2]=[CH2:3])=[O:6])[CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 121410342HCID 121410342, compound

Product 1

HCID 121410349Allyl 4-((2-aminoethyl)(4-chlorophenethyl)amino)piperidine-1-carboxylate hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-Allyloxycarbonyl-N-[2-(tert-butoxycarbonylamino)ethyl]-N-[2-(4-chlorophenyl)ethyl]-piperidin-4-amine obtained in Step 1 was subjected to the deprotection reaction as described in Procedure 2 (4 N HCl in EtOAc). The crude product that was obtained in this step was used in the synthesis of Examples 8-13 without any further purification.

Sources & evidence

ORD record
ord-2bc9a29bd965412ebae204671b6815e0
Source dataset
uspto-grants-2016_09
Patent number
US09440953B2

Reaction notes

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