HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methoxy-5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine → HCID 178430479, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methoxy-5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine | HCID 23654107 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | HCID 178430479 | HCID 178430479 | — |
Reaction Steps
2-Methoxy-5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine (1.99 g, 6.90 mmol) in 48% aq. HBr (15 ml) was heated at reflux for 18 h. Evaporation of aq. HBr rendered 1.78 g (99%) of hydrobromide salt of 5-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-2-ol. 1H-NMR (D2O) δ 7.78 (d, 1H), 6.66 (d, 1H), 3.55-3.10 (m, 7H), 1.36 (d, 3H) ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897595B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-9cdbb7254c19483a807d320f11bd2800 |
| Source note | uspto-grants-2011_03 |