HRID597908
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
2-Methoxy-5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine (1.99 g, 6.90 mmol) in 48% aq. HBr (15 ml) was heated at reflux for 18 h. Evaporation of aq. HBr rendered 1.78 g (99%) of hydrobromide salt of 5-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepin-2-ol. 1H-NMR (D2O) δ 7.78 (d, 1H), 6.66 (d, 1H), 3.55-3.10 (m, 7H), 1.36 (d, 3H) ppm.
WORKUP
后处理
- temperatureat reflux for 18 h
- customEvaporation of aq. HBr