反应详情

温度

25 °C

To a solution containing 0.55 g (3.57 mmol) of 1-methyl-5-nitropyridin-2(1H)-one in 10 ml of N,N-dimethylformamide under a nitrogen atm. was added 0.76 g (4.27 mmol) of N-bromosuccinimide. The reaction was allowed to stir at 25° C. overnight. The reaction was diluted with dichloromethane and washed with water. The organic phase was dried over magnesium sulfate. Filtration, removal of solvent and purification of the residue via biotage eluting with 70% ethyl acetate/hexanes gave 0.60 g (72.15%) of product as a white solid.

1. washwashed with water
2. dry with materialThe organic phase was dried over magnesium sulfate
3. filtrationFiltration, removal of solvent and purification of the residue via biotage
4. washeluting with 70% ethyl acetate/hexanes