Hydrazine → 6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione

HRID 598061Notes

Reaction equation

HRID 598061 reaction equation
Cl[C:2]1[NH:7][C:6](=[O:8])[N:5]([CH3:9])[C:4](=[O:10])[CH:3]=1.[NH2:11][NH2:12]>C(O)C>[NH:11]([C:2]1[NH:7][C:6](=[O:8])[N:5]([CH3:9])[C:4](=[O:10])[CH:3]=1)[NH2:12]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 961416-chloro-3-methylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 113786296-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dioneYield 99.74%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

To a mixture containing 10.0 g (62.28 mmol) of 6-chloro-3-methyluracil in 200 ml of ethanol was added 13.70 ml (436.50 mmol) of hydrazine. The mixture was heated to 75° C. under a nitrogen atmosphere overnight. The solids were filtered, washed with ethanol and dried to afford 9.70 g (99.74%) of product as a pale yellow solid.

Workup

  1. filtrationThe solids were filtered
  2. washwashed with ethanol
  3. customdried

Sources & evidence

ORD record
ord-e526bf6864e8423ca164bffe33cbfb8e
Source dataset
uspto-grants-2011_03
Patent number
US07897607B2

Reaction notes

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