Ethanol → HCID 178418619, compound

HRID 5981Notes

Reaction equation

HRID 5981 reaction equation
[C:1]1([CH:7]2[CH:12]([N:13]3[CH:17]=[CH:16][N:15]=[CH:14]3)[C:11](=O)[C:10]3[CH:19]=[CH:20][CH:21]=[CH:22][C:9]=3[O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:24][OH:25].[CH2:26]([OH:28])[CH3:27]>N1C=CC=CC=1>[CH2:26]([O:28][C:7](=[O:8])[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][O:25]/[N:24]=[C:11]1\[CH:12]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)[CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[O:8][C:9]2[CH:22]=[CH:21][CH:20]=[CH:19][C:10]\1=2)[CH3:27]

Participants

5

Reactant 3

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 13135472(+-)-2-phenyl-3-(1H-imidazol-1-yl)-2,3-dihydro-4H-benzopyran-4-one

Product 1

HCID 178418619HCID 178418619, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

As an example the intermediate oxime used as starting material can be prepared as follows: (+-)-2-phenyl-3-(1H-imidazol-1-yl)-2,3-dihydro-4H-benzopyran-4-one[J. Het. Chem. 21,311,(1984)], (4 g.; 0.014 moles), is dissolved in pyridine, and hydroxylamine hydrochloride (2.4 g.; 0.034 moles) dissolved in ethanol (20 ml), is added at room temperature to the solution.

Workup

  1. customcan be prepared
  2. additionis added at room temperature to the solution

Sources & evidence

ORD record
ord-ec948c710b104c45b379cfa5db96a444
Source dataset
uspto-grants-1993_09
Patent number
US05246956

Reaction notes

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