Potassium Hydroxide → HCID 58938534, compound

HRID 598100Notes

Reaction equation

HRID 598100 reaction equation
[CH2:1]([N:4]([CH2:30][CH2:31][CH3:32])[C:5]1[CH:6]=[C:7](C(OCC)=O)[C:8](=[O:24])[N:9]2[C:14]=1[CH:13]=[CH:12][CH:11]=[C:10]2[C:15]1[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=1[CH3:23])[CH2:2][CH3:3].[OH-].[K+]>C(O)C>[CH2:30]([N:4]([CH2:1][CH2:2][CH3:3])[C:5]1[CH:6]=[CH:7][C:8](=[O:24])[N:9]2[C:14]=1[CH:13]=[CH:12][CH:11]=[C:10]2[C:15]1[C:16]([CH3:23])=[CH:17][C:18]([CH3:22])=[CH:19][C:20]=1[CH3:21])[CH2:31][CH3:32]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 58938583HCID 58938583, compound

Product 1

HCID 58938534HCID 58938534, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

Ethyl 1-(dipropylamino)-6-mesityl-4-oxo-4H-quinolizine-3-carboxylate (0.0145 g, 0.033 mmol) was dissolved in ethanol (0.3 mL). Potassium hydroxide (6M in ethanol, 94 μL, 0.57 mmol) was added. The solution was heated at 60° C. for 1 h. The solution was extracted using ethyl acetate, dried over magnesium sulfate and concentrated to give 0.010 g (83% yield) of the title compound.

Workup

  1. extractionThe solution was extracted
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-4db8714ab5fd429e9647b5df2bba433f
Source dataset
uspto-grants-2011_03
Patent number
US07897607B2

Reaction notes

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