反应详情

温度

100 °C

Diethyl [1-ethoxy-2-(6-mesitylpyridin-2-yl)-3-oxohexyl]malonate (0.045 g, 0.10 mmol) was dissolved in acetic acid (3 mL). The reaction was heated at 100° C. for 20 minutes. Acetic acid was stripped off via rotavap. Saturated sodium bicarbonate was added and the solution was extracted with ethyl acetate. The organics were dried, concentrated, and flash chromatographed (20% ethyl acetate/hexanes) to give 0.015 g (37% yield) of the title compound.

1. extractionthe solution was extracted with ethyl acetate
2. customThe organics were dried
3. concentrationconcentrated
4. customflash chromatographed (20% ethyl acetate/hexanes)