反应详情

To 0.42 g (1.4 mmol) of 1-benzyl-5-chloro-3-hydroxymethylcinnolin-4(1H)-one in 25 mL of dichloromethane at 0° C. was added 0.97 mL (7.0 mmol) of triethylamine and 0.33 mL (4.2 mmol) of methanesulfonyl chloride. The reaction was allowed to warm to room temperature and stirred for 5 h. The reaction was concentrated by rotary evaporation and was subsequently dissolved in dichloromethane and concentrated onto silica gel. The crude material was purified by flash chromatography eluting with a 33-50% ethyl acetate/hexanes gradient mixture to give 0.26 g (59%) of the title compound as an off-white solid.

1. concentrationThe reaction was concentrated by rotary evaporation
2. dissolutionwas subsequently dissolved in dichloromethane
3. concentrationconcentrated onto silica gel
4. customThe crude material was purified by flash chromatography
5. washeluting with a 33-50% ethyl acetate/hexanes gradient mixture