1-Benzyl-5-(2,4-dimethylphenyl)-3-methylcinnolin-4(1H)-one → 5-(2,4-Dimethylphenyl)-3-methylcinnolin-4(1H)-one

Beteiligte Stoffe

Reaktionsschritte

To 0.122 g (0.34 mmol) of 1-benzyl-5-(2,4-dimethylphenyl)-3-methylcinnolin-4(1H)-one and 0.14 g (0.10 mmol Pd) of 10% Pearlman's catalyst was added 4 mL of ethanol and two drops of concentrated HCl. The reaction vessel was charged with hydrogen via a balloon and stirred at room temperature for 3 h. The catalyst was removed by filtration, the filtrate was concentrated and the residue was purified by flash chromatography eluting with a 33% ethyl acetate/hexanes mixture to give 0.047 g (52%) of product as a white solid.

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