反应详情

To 0.122 g (0.34 mmol) of 1-benzyl-5-(2,4-dimethylphenyl)-3-methylcinnolin-4(1H)-one and 0.14 g (0.10 mmol Pd) of 10% Pearlman's catalyst was added 4 mL of ethanol and two drops of concentrated HCl. The reaction vessel was charged with hydrogen via a balloon and stirred at room temperature for 3 h. The catalyst was removed by filtration, the filtrate was concentrated and the residue was purified by flash chromatography eluting with a 33% ethyl acetate/hexanes mixture to give 0.047 g (52%) of product as a white solid.

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated
3. customthe residue was purified by flash chromatography
4. washeluting with a 33% ethyl acetate/hexanes mixture