Phosgene → HCID 67268202, compound

HRID 598196Notes

Reaction equation

HRID 598196 reaction equation
[NH2:1][C:2]1[C:3]([CH3:20])=[N:4][N:5]([C:11]2[C:16]([Cl:17])=[CH:15][C:14]([Cl:18])=[CH:13]C=2Cl)[C:6]=1[C:7]([NH:9][CH3:10])=[O:8].[C:21]([Cl:24])(Cl)=O.[O:25]1CCC[CH2:26]1>>[CH3:20][C:3]1[C:2]2[NH:1][C:26](=[O:25])[N:9]([CH3:10])[C:7](=[O:8])[C:6]=2[N:5]([C:11]2[C:16]([Cl:17])=[CH:15][C:14]([Cl:18])=[CH:13][C:21]=2[Cl:24])[N:4]=1

Participants

4

Reactant 3

HCID 6371PhosgeneHCID 8028TetrahydrofuranHCID 67267294HCID 67267294, compound

Product 1

HCID 67268202HCID 67268202, compound

Procedure

To a solution of 4 amino-N,3-dimethyl-1-(2,4,6-trichlorophenyl)-1H-pyrazole-5-carboxamide (20 mg, 0.0600 mmol) in tetrahydrofuran (1 ml) was added phosgene (20% solution in tetrahydrofuran, 0.048 ml) and the mixture was stirred at room temperature for 2 h. The solvent was evaporated under vacuum to give the title compound, which was used for the next step without further purification.

Workup

  1. customThe solvent was evaporated under vacuum

Sources & evidence

ORD record
ord-76266c822b294a989ada4067b6d1a4c8
Source dataset
uspto-grants-2011_03
Patent number
US07897607B2

Reaction notes

Loading…