反应详情

1-Methyl-1,3-dihydroimidazo[4,5-b]pyridin-2-one (75 mg, 0.5 mmol) and 1-isocyanatohexane (64 mg, 0.5 mmol) were stirred at 80° C. in 3.5 ml of dioxane for 4 h. The reaction mixture was concentrated and purified by means of preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 40 mg (29%), M+H+: 277.16.

1. concentrationThe reaction mixture was concentrated
2. custompurified by means of preparative HPLC (PR18, acetonitrile/water 0.1% TFA)