HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexyl isocyanate → N-Hexyl-1-methyl-2-oxo-1,2-dihydroimidazo[4,5-b]pyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexyl isocyanate | HCID 75659 | — |
| Reactant | 1-Methyl-1h-imidazo[4,5-b]pyridin-2(3h)-one | HCID 854236 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-Hexyl-1-methyl-2-oxo-1,2-dihydroimidazo[4,5-b]pyridine-3-carboxamide | HCID 16747772 | — |
Reaction Steps
1-Methyl-1,3-dihydroimidazo[4,5-b]pyridin-2-one (75 mg, 0.5 mmol) and 1-isocyanatohexane (64 mg, 0.5 mmol) were stirred at 80° C. in 3.5 ml of dioxane for 4 h. The reaction mixture was concentrated and purified by means of preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 40 mg (29%), M+H+: 277.16.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897616B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-ce463efdb43849f093bb4cc2036bd1ce |
| Source note | uspto-grants-2011_03 |