Toluene → N-Hexyl-7-methyl-2-oxo-1,2-dihydroimidazo[4,5-c]pyridine-3-carboxamide

HRID 598202Notes

Reaction equation

[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[NH:3][C:2]1=[O:10].[N:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[C:12]=[O:13].[C:20]1(C)C=CC=CC=1>>[CH2:14]([NH:11][C:12]([N:3]1[C:4]2[CH:5]=[N:6][CH:7]=[C:8]([CH3:20])[C:9]=2[NH:1][C:2]1=[O:10])=[O:13])[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

Participants

Reactant 3

HCID 1140Toluene

HCID 75659Hexyl isocyanate

HCID 116869163H-Imidazo[4,5-c]pyridin-2-ol

Product 1

HCID 67268408N-Hexyl-7-methyl-2-oxo-1,2-dihydroimidazo[4,5-c]pyridine-3-carboxamide

Procedure

Analogously to Example 1, 2 g (14.8 mmol) of 1,3-dihydroimidazo[4,5-c]pyridin-2-one and 1-isocyanatohexane (2.26 g, 17.76 mmol) were reacted in toluene. Yield: 43 mg (1%), M+H+: 263.19.

Sources & evidence

ORD record: ord-42ff90f4494d4f448037cbeda38cdd5a
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07897616B2

Reaction notes

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