Piconol → 5-Bromo-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinic acid ethyl ester

HRID 598251Notes

Reaction equation

HRID 598251 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10]([Br:12])[C:9](=[O:13])[NH:8][C:7]=1[C:14]([F:17])([F:16])[F:15])=[O:5])[CH3:2].O[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1>>[CH2:1]([O:3][C:4](=[O:5])[C:6]1[CH:11]=[C:10]([Br:12])[C:9]([O:13][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)=[N:8][C:7]=1[C:14]([F:17])([F:15])[F:16])[CH3:2]

Participants

3

Reactant 2

HCID 11474PiconolHCID 57900861Ethyl 5-bromo-6-hydroxy-2-(trifluoromethyl)nicotinate

Product 1

HCID 574463005-Bromo-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinic acid ethyl ester

Procedure

The title compound was synthesized in analogy to Example 1a, using 5-bromo-1,6-dihydro-6-oxo-2-(trifluoromethyl)-3-pyridinecarboxylic acid ethyl ester (CAS Registry No. 862111-61-3) and 2-(hydroxymethyl)-pyridine as starting materials, MS (ISP) 407.1 (M+H)+.

Sources & evidence

ORD record
ord-0aaa845808a84d6d8b4468e687107b96
Source dataset
uspto-grants-2011_03
Patent number
US07897621B2

Reaction notes

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