L-Leucinol → 5-bromo-N-(1-hydroxymethyl-3-methyl-butyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide

HRID 598252Notes

Reaction equation

HRID 598252 reaction equation
[Br:1][C:2]1[C:3]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)=[N:4][C:5]([C:11]([F:14])([F:13])[F:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[NH2:23][C@H:24]([CH2:29][OH:30])[CH2:25][CH:26]([CH3:28])[CH3:27]>>[Br:1][C:2]1[C:3]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)=[N:4][C:5]([C:11]([F:14])([F:13])[F:12])=[C:6]([CH:10]=1)[C:7]([NH:23][CH:24]([CH2:29][OH:30])[CH2:25][CH:26]([CH3:28])[CH3:27])=[O:9]

Participants

3

Reactant 2

HCID 111307L-LeucinolHCID 574463015-Bromo-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinic acid

Product 1

HCID 689723205-bromo-N-(1-hydroxymethyl-3-methyl-butyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1c, using 5-bromo-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinic acid and rac-leucinol as starting materials, MS (ISP) 476.1 (M+H)+.

Sources & evidence

ORD record
ord-19a992d3c9654d879130d7a478267dd9
Source dataset
uspto-grants-2011_03
Patent number
US07897621B2

Reaction notes

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