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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 598252Generated: October 26, 2026

L-Leucinol → 5-bromo-N-(1-hydroxymethyl-3-methyl-butyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide

https://huagongshe.com/reaction/598252

Reaction equation

Participants

RoleNameHCIDCharge
ReactantL-LeucinolHCID 111307—
Reactant5-Bromo-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinic acidHCID 57446301—
Product5-bromo-N-(1-hydroxymethyl-3-methyl-butyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamideHCID 68972320—

Reaction Steps

The title compound was synthesized in analogy to Example 1c, using 5-bromo-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinic acid and rac-leucinol as starting materials, MS (ISP) 476.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07897621B2
Source datasetuspto-grants-2011_03
ORD IDord-19a992d3c9654d879130d7a478267dd9
Source noteuspto-grants-2011_03