(4-Methanesulfonamidophenyl)boronic acid → N-(1-Hydroxymethyl-3-methyl-butyl)-5-(4-methanesulfonylamino-phenyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide

HRID 598253노트

반응식

HRID 598253 반응식
Br[C:2]1[C:3]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)=[N:4][C:5]([C:18]([F:21])([F:20])[F:19])=[C:6]([CH:17]=1)[C:7]([NH:9][CH:10]([CH2:15][OH:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8].[CH3:30][S:31]([NH:34][C:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1)(=[O:33])=[O:32]>>[OH:16][CH2:15][CH:10]([NH:9][C:7](=[O:8])[C:6]1[CH:17]=[C:2]([C:38]2[CH:37]=[CH:36][C:35]([NH:34][S:31]([CH3:30])(=[O:32])=[O:33])=[CH:40][CH:39]=2)[C:3]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)=[N:4][C:5]=1[C:18]([F:21])([F:20])[F:19])[CH2:11][CH:12]([CH3:14])[CH3:13]

참가 물질

3

반응물 2

HCID 2773537(4-Methanesulfonamidophenyl)boronic acidHCID 689723205-bromo-N-(1-hydroxymethyl-3-methyl-butyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide

생성물 1

HCID 44240773N-(1-Hydroxymethyl-3-methyl-butyl)-5-(4-methanesulfonylamino-phenyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide

실험 절차

The title compound was synthesized in analogy to Example 1d, using 5-bromo-N-(1-hydroxymethyl-3-methyl-butyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide and 4-methanesulfonylaminophenylboronic acid as starting materials, MS (ISP) 567.2 (M)+.

출처 및 근거

ORD 기록
ord-3f7ce8b0d07c493c95e08ce6e2fd1ce3
출처 데이터셋
uspto-grants-2011_03
특허 번호
US07897621B2

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