HRID598253

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2773537

{4-[(Methanesulfonyl)amino]phenyl}boronic acid

C7H10BNO4S

结构：CC(C)CC(CO)NC(=O)c1cc(Br)c(OCc2ccccn2)nc1C(F)(F)F

HCID68972320

未命名化合物

PRODUCTS

生成物

结构：CC(C)CC(CO)NC(=O)c1cc(-c2ccc(NS(C)(=O)=O)cc2)c(OCc2ccccn2)nc1C(F)(F)F

HCID44240773

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 1d, using 5-bromo-N-(1-hydroxymethyl-3-methyl-butyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide and 4-methanesulfonylaminophenylboronic acid as starting materials, MS (ISP) 567.2 (M)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3f7ce8b0d07c493c95e08ce6e2fd1ce3
来源数据集: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07897621B2
来源说明: uspto-grants-2011_03

反应 SMILES

Br[C:2]1[C:3]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)=[N:4][C:5]([C:18]([F:21])([F:20])[F:19])=[C:6]([CH:17]=1)[C:7]([NH:9][CH:10]([CH2:15][OH:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8].[CH3:30][S:31]([NH:34][C:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1)(=[O:33])=[O:32]>>[OH:16][CH2:15][CH:10]([NH:9][C:7](=[O:8])[C:6]1[CH:17]=[C:2]([C:38]2[CH:37]=[CH:36][C:35]([NH:34][S:31]([CH3:30])(=[O:32])=[O:33])=[CH:40][CH:39]=2)[C:3]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)=[N:4][C:5]=1[C:18]([F:21])([F:20])[F:19])[CH2:11][CH:12]([CH3:14])[CH3:13]