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HRID 598253作成日：2026年10月25日

(4-Methanesulfonamidophenyl)boronic acid → N-(1-Hydroxymethyl-3-methyl-butyl)-5-(4-methanesulfonylamino-phenyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide

https://huagongshe.com/reaction/598253

反応式

関与物質

役割名称HCID仕込み量
反応物(4-Methanesulfonamidophenyl)boronic acidHCID 2773537—
反応物5-bromo-N-(1-hydroxymethyl-3-methyl-butyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamideHCID 68972320—
生成物N-(1-Hydroxymethyl-3-methyl-butyl)-5-(4-methanesulfonylamino-phenyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamideHCID 44240773—

反応手順

The title compound was synthesized in analogy to Example 1d, using 5-bromo-N-(1-hydroxymethyl-3-methyl-butyl)-6-(pyridin-2-ylmethoxy)-2-trifluoromethyl-nicotinamide and 4-methanesulfonylaminophenylboronic acid as starting materials, MS (ISP) 567.2 (M)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07897621B2
出典データセットuspto-grants-2011_03
ORD IDord-3f7ce8b0d07c493c95e08ce6e2fd1ce3
出典メモuspto-grants-2011_03