反应详情

tert-Butyl [4-(6-benzyloxy-3-nitroquinolin-4-ylamino)butyl]carbamate (17.62 g, 37.77 mmol) was dissolved in toluene (600 mL) with heating and added to a Parr vessel charged with 5% platinum on carbon (2.20 g). The vessel was placed under hydrogen pressure (30 psi, 2.1×105 Pa) for three hours. The reaction mixture was filtered through a layer of CELITE filter aid, and the filtrate was concentrated under reduced pressure to provide 15.5 g of tert-butyl {4-[3-amino-6-(benzyloxy)quinolin-4-ylamino]butyl}carbamate as a brown solid.

1. temperaturewith heating
2. additionadded to a Parr vessel
3. customfor three hours
4. filtrationThe reaction mixture was filtered through a layer of CELITE
5. filtrationfilter aid
6. concentrationthe filtrate was concentrated under reduced pressure