Triethylamine → HCID 57748969, compound

HRID 598513Notes

Reaction equation

HRID 598513 reaction equation
Cl[C:2]1[O:3][C:4]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH2:12]([N:19]1[CH2:23][CH2:22][C@@H:21]([NH:24][CH3:25])[CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.CCN(CC)CC>C(Cl)Cl>[CH2:12]([N:19]1[CH2:23][CH2:22][C@@H:21]([N:24]([C:2]2[O:3][C:4]3[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:5]=3[N:6]=2)[CH3:25])[CH2:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 771752,6-DichlorobenzoxazoleHCID 10035441(3R)-(-)-1-Benzyl-3-(methylamino)pyrrolidine

Product 1

HCID 57748969HCID 57748969, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture of 0.5 g (2.6 mmol) 2,6-dichloro benzoxazole, 0.68 g (3.58 mmol) ((R)-1-benzyl-pyrrolidin-3-yl)-methyl-amine and 0.4 g (4 mmol) NEt3 in 12 mL DCM was stirred over night at room temperature. DCM was added and the mixture was washed with NaHCO3 aq., dried with MgSO4 and evaporated to dryness to yield the title compound as yellow oil which was used in the consecutive step without further purification. (MH+) 342.1

Workup

  1. washthe mixture was washed with NaHCO3 aq.
  2. dry with materialdried with MgSO4
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-a25da6b679d84e829ccfc82af6ac1688
Source dataset
uspto-grants-2011_03
Patent number
US07897627B2

Reaction notes

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