3-Chloro-6-(trifluoromethyl)pyridazine → (5-Methyl-2-trifluoromethyl-phenyl)-[(R)-3-(6-trifluoromethyl-pyridazin-3-ylamino)-pyrrolidin-1-yl]-methanone

HRID 598518Notes

Reaction equation

HRID 598518 reaction equation
[NH2:1][C@@H:2]1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][C:10]=2[C:16]([F:19])([F:18])[F:17])=[O:8])[CH2:3]1.Cl[C:21]1[N:22]=[N:23][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:25][CH:26]=1>>[CH3:15][C:13]1[CH:12]=[CH:11][C:10]([C:16]([F:19])([F:17])[F:18])=[C:9]([C:7]([N:4]2[CH2:5][CH2:6][C@@H:2]([NH:1][C:21]3[N:22]=[N:23][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:25][CH:26]=3)[CH2:3]2)=[O:8])[CH:14]=1

Participants

3

Reactant 2

HCID 282425263-Chloro-6-(trifluoromethyl)pyridazineHCID 57748952((R)-3-Amino-pyrrolidin-1-yl)-(5-methyl-2-trifluoromethyl-phenyl)-methanone2×

Product 1

HCID 57748947(5-Methyl-2-trifluoromethyl-phenyl)-[(R)-3-(6-trifluoromethyl-pyridazin-3-ylamino)-pyrrolidin-1-yl]-methanone

Procedure

In analogy to the procedure described for example 200, the title compound was prepared from ((R)-3-Amino-pyrrolidin-1-yl)-(5-methyl-2-trifluoromethyl-phenyl)-methanone (intermediate 13) and 3-chloro-6-trifluoromethyl-pyridazine (commercially available). (MH+) 419.3.

Sources & evidence

ORD record
ord-5be49d4f07b14bd6bf6c6fcc03cd275e
Source dataset
uspto-grants-2011_03
Patent number
US07897627B2

Reaction notes

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