HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-6-(trifluoromethyl)pyridazine → (5-Methyl-2-trifluoromethyl-phenyl)-[(R)-3-(6-trifluoromethyl-pyridazin-3-ylamino)-pyrrolidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-6-(trifluoromethyl)pyridazine | HCID 28242526 | — |
| Reactant | ((R)-3-Amino-pyrrolidin-1-yl)-(5-methyl-2-trifluoromethyl-phenyl)-methanone | HCID 57748952 | — |
| Product | (5-Methyl-2-trifluoromethyl-phenyl)-[(R)-3-(6-trifluoromethyl-pyridazin-3-ylamino)-pyrrolidin-1-yl]-methanone | HCID 57748947 | — |
Reaction Steps
In analogy to the procedure described for example 200, the title compound was prepared from ((R)-3-Amino-pyrrolidin-1-yl)-(5-methyl-2-trifluoromethyl-phenyl)-methanone (intermediate 13) and 3-chloro-6-trifluoromethyl-pyridazine (commercially available). (MH+) 419.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897627B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-5be49d4f07b14bd6bf6c6fcc03cd275e |
| Source note | uspto-grants-2011_03 |