2-Chloro-6-(trifluoromethyl)quinoxaline → (5-Methyl-2-trifluoromethyl-phenyl)-[(R)-3-(6-trifluoromethyl-quinoxalin-2-ylamino)-pyrrolidin-1-yl]-methanone

HRID 598525Notes

Reaction equation

HRID 598525 reaction equation
Cl[C:2]1[CH:11]=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=2)[N:3]=1.[NH2:16][C@@H:17]1[CH2:21][CH2:20][N:19]([C:22]([C:24]2[CH:29]=[C:28]([CH3:30])[CH:27]=[CH:26][C:25]=2[C:31]([F:34])([F:33])[F:32])=[O:23])[CH2:18]1>>[CH3:30][C:28]1[CH:27]=[CH:26][C:25]([C:31]([F:34])([F:32])[F:33])=[C:24]([C:22]([N:19]2[CH2:20][CH2:21][C@@H:17]([NH:16][C:2]3[CH:11]=[N:10][C:9]4[C:4](=[CH:5][CH:6]=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=4)[N:3]=3)[CH2:18]2)=[O:23])[CH:29]=1

Participants

3

Reactant 2

HCID 35473422-Chloro-6-(trifluoromethyl)quinoxalineHCID 57748952((R)-3-Amino-pyrrolidin-1-yl)-(5-methyl-2-trifluoromethyl-phenyl)-methanone2×

Product 1

HCID 57748860(5-Methyl-2-trifluoromethyl-phenyl)-[(R)-3-(6-trifluoromethyl-quinoxalin-2-ylamino)-pyrrolidin-1-yl]-methanone

Procedure

In analogy to the procedure described for example 200, the title compound was prepared from 2-chloro-6-trifluoromethyl-quinoxaline and ((R)-3-amino-pyrrolidin-1-yl)-(5-methyl-2-trifluoromethyl-phenyl)-methanone (intermediate 13). (M+H+) 469.2.

Sources & evidence

ORD record
ord-cfd0afe295f948b0be04cc070eb2aac4
Source dataset
uspto-grants-2011_03
Patent number
US07897627B2

Reaction notes

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