Benzeneacetonitrile, 4-fluoro- → HCID 73051256, compound

HRID 59853Notes

Reaction equation

HRID 59853 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-])=[O:20])=[CH:15][CH:14]=2)=[CH:11][CH:10]=[N:9]1.[F:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29]C#N)=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]3=[N:19][O:20][C:29]([C:26]4[CH:27]=[CH:28][C:23]([F:22])=[CH:24][CH:25]=4)=[C:15]3[CH:14]=2)=[CH:11][CH:10]=[N:9]1

Participants

3

Reactant 2

HCID 68016Benzeneacetonitrile, 4-fluoro-HCID 900325511-(2-chloro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole2×

Product 1

HCID 73051256HCID 73051256, compound

Procedure

The title compound, green solid (53 mg, 41%), MS (ISP) m/z=390.2 [(M+H)+], mp 161° C., was prepared in accordance with the general method of example 1 from 1-(2-chloro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate L) (100 mg, 353 μmol) and commercially available 2-(4-fluoro-phenyl)-acetonitrile.

Sources & evidence

ORD record
ord-74d0ce3b928a4390bcc45a40b8c6d8d2
Source dataset
uspto-grants-2016_09
Patent number
US09440962B2

Reaction notes

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