反应详情

A solution of (RS)-2-(2-benzofuranylcarbonyl)-1-(tert-butyloxycarbonyl)piperidine, D2 (0.86 g, 2.61 mmol) in trifluoroacetic acid (5 ml) and dichloromethane (20 ml) was warmed at 35° C. for 0.5 h. The reaction mixture was evaporated in vacuo and the residue partitioned between dichloromethane (30 ml) and 1N sodium hydroxide (30 ml). The aqueous layer was extracted with dichloromethane (30 ml) and the combined organic layers dried (Na2SO4) and evaporated in vacuo to afford the title compound as a pale yellow gum (0.59 g, 99%).

1. customThe reaction mixture was evaporated in vacuo
2. customthe residue partitioned between dichloromethane (30 ml) and 1N sodium hydroxide (30 ml)
3. extractionThe aqueous layer was extracted with dichloromethane (30 ml)
4. dry with materialthe combined organic layers dried (Na2SO4)
5. customevaporated in vacuo