Diisopropylethylamine → HCID 11168950, compound

HRID 598727Notes

Reaction equation

HRID 598727 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:14]([F:17])([F:16])[F:15])[C:8]([O:12][CH3:13])=[C:9]([NH2:11])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[N:18]1([CH2:24][CH2:25][O:26][C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:30]([C:37](=[O:41])[C:38](Cl)=[O:39])=[CH:29][CH:28]=2)[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1.CCN(C(C)C)C(C)C>C(Cl)Cl>[C:1]([C:5]1[CH:6]=[C:7]([C:14]([F:15])([F:16])[F:17])[C:8]([O:12][CH3:13])=[C:9]([NH:11][C:38](=[O:39])[C:37]([C:30]2[C:31]3[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:27]([O:26][CH2:25][CH2:24][N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)=[CH:28][CH:29]=2)=[O:41])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 57503080HCID 57503080, compoundHCID 59379806HCID 59379806, compound

Product 1

HCID 11168950HCID 11168950, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-tert-Butyl-2-methoxy-3-trifluoromethyl-phenylamine (32 mg, 0.165 mmol) was dissolved in 2 mL DCM. [4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-oxo-acetyl chloride (0.232 mmol), prepared as described before, and DIEA (0.02 mL, 0.50 mmol) were added and the reaction was stirred on. The reaction mixture was evaporated and the residue was purified by LC/MS (10-100% AcN). Calculated mass=558. Observed mass=559

Workup

  1. additionwere added
  2. customThe reaction mixture was evaporated
  3. customthe residue was purified by LC/MS (10-100% AcN)

Sources & evidence

ORD record
ord-f295a0b959684b97936a5058713db860
Source dataset
uspto-grants-2011_03
Patent number
US07897599B2

Reaction notes

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