Hydrochloric Acid → HCID 58256798, compound

HRID 598795Notes

Reaction equation

HRID 598795 reaction equation
O1[C:5]2([CH2:10][CH2:9][CH:8]([N:11]3[C:15]([CH:16]([CH3:18])[CH3:17])=[CH:14][C:13]([CH:19]([CH3:21])[CH3:20])=[N:12]3)[CH2:7][CH2:6]2)[O:4]CC1.Cl>CC(C)=O>[CH:19]([C:13]1[CH:14]=[C:15]([CH:16]([CH3:18])[CH3:17])[N:11]([CH:8]2[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]2)[N:12]=1)([CH3:20])[CH3:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58256813HCID 58256813, compound

Product 1

HCID 58256798HCID 58256798, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-3,5-diisopropyl-1H-pyrazole (40 mg) in acetone (20 ml) was added HCl (20 mL, 2M aq). The reaction was heated to reflux overnight. The reaction was cooled, concentrated and extracted with EtOAc. The organic fractions were washed with water, saturated NaHCO3 and dried over Na2SO4. The solution was concentrated and used without further purification (Yield 30.6 mg). LC-MS (C15H24N2O calculated 248) m/z 249 (M+H).

Workup

  1. temperatureThe reaction was heated
  2. temperatureto reflux overnight
  3. temperatureThe reaction was cooled
  4. concentrationconcentrated
  5. extractionextracted with EtOAc
  6. washThe organic fractions were washed with water, saturated NaHCO3
  7. dry with materialdried over Na2SO4
  8. concentrationThe solution was concentrated
  9. customused without further purification (Yield 30.6 mg)

Sources & evidence

ORD record
ord-de0509419776433fb1aaf0a03ffbf94a
Source dataset
uspto-grants-2011_03
Patent number
US07897634B2

Reaction notes

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