Trifluoroacetic acid → HCID 178434255, compound

HRID 598830Notes

Reaction equation

HRID 598830 reaction equation
COC1C=CC(C[NH:8][C:9]2[O:10][C:11]([C:14]3[CH:15]=[C:16]4[C:20](=[CH:21][CH:22]=3)[NH:19][N:18]=[C:17]4[CH3:23])=[CH:12][N:13]=2)=CC=1.C(O)(C(F)(F)F)=O>C1(C)C=CC=CC=1>[CH3:23][C:17]1[C:16]2[C:20](=[CH:21][CH:22]=[C:14]([C:11]3[O:10][C:9]([NH2:8])=[N:13][CH:12]=3)[CH:15]=2)[NH:19][N:18]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178490979N-(4-methoxybenzyl)-5-(3-methyl-1H-indazol-5-yl)oxazol-2-amine

Product 1

HCID 178434255HCID 178434255, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
150 °C

Procedure

A glass microwave reaction vessel was charged with N-(4-methoxybenzyl)-5-(3-methyl-1H-indazol-5-yl)oxazol-2-amine (196 mg, 587 μmol) and TFA (2.00 mL). The reaction mixture was stirred and heated in a Smith Synthesizer® microwave reactor (Personal Chemistry, Inc., Upssala, Sweden) at 150° C. for 6 minutes. Toluene was added and the solvents were removed in vacuo to give the desired product. The residual material was treated with 2.0 M NH3 in MeOH and 1 N NaOH and the resulting precipitate was filtered to give a yellow solid which was used without further purification.

Workup

  1. customA glass microwave reaction vessel
  2. customthe solvents were removed in vacuo

Sources & evidence

ORD record
ord-9dd5aae3ee84478f9683c51b03e8be44
Source dataset
uspto-grants-2011_03
Patent number
US07897619B2

Reaction notes

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