N-((1,1-Dimethylethoxy)carbonyl)-4-(trifluoromethyl)-L-phenylalanine → HCID 178434254、化合物

HRID 598831ノート

反応式

HRID 598831 の反応式
C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.[CH3:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([C:25]3[O:29][C:28]([NH2:30])=[N:27][CH:26]=3)[CH:23]=2)[NH:18][N:17]=1.[C:31]([O:35][C:36]([NH:38][C@@H:39]([CH2:43][C:44]1[CH:49]=[CH:48][C:47]([C:50]([F:53])([F:52])[F:51])=[CH:46][CH:45]=1)[C:40](O)=[O:41])=[O:37])([CH3:34])([CH3:33])[CH3:32]>>[CH3:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([C:25]3[O:29][C:28]([NH:30][C:40](=[O:41])[C@@H:39]([NH:38][C:36](=[O:37])[O:35][C:31]([CH3:32])([CH3:33])[CH3:34])[CH2:43][C:44]4[CH:45]=[CH:46][C:47]([C:50]([F:53])([F:52])[F:51])=[CH:48][CH:49]=4)=[N:27][CH:26]=3)[CH:23]=2)[NH:18][N:17]=1

参加物

4

反応物 3

HCID 7021025N-((1,1-Dimethylethoxy)carbonyl)-4-(trifluoromethyl)-L-phenylalanineHCID 86583742Edc hobtHCID 178434255HCID 178434255、化合物

生成物 1

HCID 178434254HCID 178434254、化合物

実験手順

This intermediate was prepared by EDC-HOBt coupling of 5-(3-methyl-1H-indazol-5-yl)oxazol-2-amine with (S)-2-(tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)propanoic acid (purchased from Peptech (CAS No. 114873-07-3)) using a standard procedure such as described in Bioorg. Med. Chem. 14(2), 418-425; 2006) which is hereby incorporated by reference in its entirety as if specifically set forth herein.

出典と根拠

ORDレコード
ord-45aea12d31a34f1c96e3f322e8b69387
出典データセット
uspto-grants-2011_03
特許番号
US07897619B2

反応ノート

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