化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(3-Methoxy-2-methoxycarbonylphenoxy)-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | Methyl 2-hydroxy-6-methoxybenzoate | HCID 527092 | — |
| 反応物 | 2-(3-Methoxy-2-methoxycarbonylphenoxy)aniline | HCID 66998871 | — |
| 生成物 | N-[(3-methoxy-2-methoxycarbonylphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732821 | 65% |
| 生成物 | 2-(3-Methoxy-2-methoxycarbonylphenoxy)-1-nitrobenzene | HCID 66998834 | 80% |
反応手順
2-(3-Methoxy-2-methoxycarbonylphenoxy)-1-nitrobenzene (1.21 g, 80%) was prepared from methyl 6-methoxysalicylate (1.09 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(3-methoxy-2-methoxycarbonylphenoxy)aniline (0.82 g, 75%) following the general procedure C. N-[(3-methoxy-2-methoxycarbonylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (130 mg, 65%) was prepared from 2-(3-methoxy-2-methoxycarbonylphenoxy)aniline (136 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-8884cacf089f4f05a95a88a729a35def |
| 出典メモ | uspto-grants-2011_03 |