HRID598945

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2155

2-Aminothiazole

C3H4N2S

HCID73895

Benzene, 1-fluoro-2-nitro-

C6H4FNO2

HCID527092

Methyl 2-hydroxy-6-methoxybenzoate

C9H10O4

HCID66998871

未命名化合物

2 次

PRODUCTS

生成物

结构：COC(=O)c1c(OC)cccc1Oc1ccccc1NC(=O)Nc1nccs1

HCID59732821

未命名化合物

收率 65%

结构：COC(=O)c1c(OC)cccc1Oc1ccccc1[N+](=O)[O-]

HCID66998834

未命名化合物

收率 80%

PROCEDURE

实验过程

2-(3-Methoxy-2-methoxycarbonylphenoxy)-1-nitrobenzene (1.21 g, 80%) was prepared from methyl 6-methoxysalicylate (1.09 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(3-methoxy-2-methoxycarbonylphenoxy)aniline (0.82 g, 75%) following the general procedure C. N-[(3-methoxy-2-methoxycarbonylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (130 mg, 65%) was prepared from 2-(3-methoxy-2-methoxycarbonylphenoxy)aniline (136 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8884cacf089f4f05a95a88a729a35def
来源数据集: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07897628B2
来源说明: uspto-grants-2011_03

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([OH:13])[C:8]=1[C:9]([O:11][CH3:12])=[O:10].F[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N+:21]([O-:23])=[O:22].[CH3:24][O:25][C:26]1[C:27]([C:40]([O:42][CH3:43])=[O:41])=[C:28]([CH:37]=[CH:38][CH:39]=1)[O:29][C:30]1[CH:36]=[CH:35][CH:34]=[CH:33][C:31]=1[NH2:32].[NH2:44][C:45]1[S:46][CH:47]=[CH:48][N:49]=1>>[CH3:1][O:2][C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([CH:6]=[CH:5][CH:4]=1)[O:13][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N+:21]([O-:23])=[O:22].[CH3:24][O:25][C:26]1[C:27]([C:40]([O:42][CH3:43])=[O:41])=[C:28]([CH:37]=[CH:38][CH:39]=1)[O:29][C:30]1[CH:36]=[CH:35][CH:34]=[CH:33][C:31]=1[NH:32][C:7]([NH:44][C:45]1[S:46][CH:47]=[CH:48][N:49]=1)=[O:13]