Ammonia → HCID 67152113, compound

HRID 599202Notes

Reaction equation

HRID 599202 reaction equation
[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[S:13]1[C:17]2=[CH:18][N:19]=[C:20]([C:22](O)=[O:23])[CH:21]=[C:16]2[CH:15]=[CH:14]1.N>>[ClH:1].[ClH:1].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH:12][C:22]([C:20]3[CH:21]=[C:16]4[CH:15]=[CH:14][S:13][C:17]4=[CH:18][N:19]=3)=[O:23])[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 12277675thieno[2,3-c]pyridine-5-carboxylic acid(WXC09021)HCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

Product 1

HCID 67152113HCID 67152113, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and thieno[2,3-c]pyridine-5-carboxylic acid (Tetrahedron Lett. 1999, 40, 7935) according to methods A and C; yield 82 mg, 0.21 mmol (59%): 1H NMR (300 MHz, methanol-d4) δ 2.03 (d, J=14 Hz, 2H), 2.25 (s, 1H), 2.39 (d, J=14 Hz, 2H), 2.55 (s, 2H), 3.61 (s, 2H), 3.72 (s, 4H), 4.54 (s, 1H), 7.91 (d, J=5 Hz, 1H), 8.62 (d, J=5 Hz, 1H), 9.01 (s, 1H), 9.57 (s, 1H); MS (DCI/NH3) m/z 314 (M+H)+; Anal. C17H19N3OS.2HCl.1.0H2O: C, H, N.

Sources & evidence

ORD record
ord-c3e8138e1b8a4b4f86bed56d98df9ccd
Source dataset
uspto-grants-2011_03
Patent number
US07897766B2

Reaction notes

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