Phenylhydrazine → 1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine

HRID 599308Notes

Reaction equation

HRID 599308 reaction equation
[F:1][C:2]([F:9])([F:8])[C:3](=O)[CH2:4][C:5]#[N:6].[C:10]1([NH:16][NH2:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:10]1([N:16]2[C:5]([NH2:6])=[CH:4][C:3]([C:2]([F:9])([F:8])[F:1])=[N:17]2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 7516PhenylhydrazineHCID 138435404,4,4-Trifluoro-3-oxobutanenitrile

Product 1

HCID 431589511-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine

Procedure

4,4,4-Trifluoro-3-oxo-butyronitrile and phenylhydrazine were combined by the procedure of Example B11 to provide 1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5-amine. 1H-NMR (400 MHz, DMSO-d6) δ 7.59-7.50 (m, 4 H), 7.42 (m, 1 H), 5.78 (s, 1 H), 5.73 (br s, 2 H).

Sources & evidence

ORD record
ord-f2f2aa9e776940969c2def5bf61600c1
Source dataset
uspto-grants-2011_03
Patent number
US07897762B2

Reaction notes

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