HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Pyridin-4-yl-8-azabicyclo[3.2.1]octane dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane-8-carboxylate | HCID 67267778 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Pyridin-4-yl-8-azabicyclo[3.2.1]octane dihydrochloride | HCID 67267742 | — |
Reaction Steps
2.76 g of tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane-8-carboxylate and 4 ml of a 4N solution of hydrochloric acid in dioxane are placed in a 10 ml round-bottomed flask. The reaction mixture is stirred for one and a half hours. The dioxane is evaporated off and 0.341 g of 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane dihydrochloride is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07897773B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-e3fa632933b54cd9a0623c90de3a695f |
| Source note | uspto-grants-2011_03 |