Hydrochloric Acid → 3-Pyridin-4-yl-8-azabicyclo[3.2.1]octane dihydrochloride

HRID 599353Notes

Reaction equation

HRID 599353 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[CH2:13][CH:12]3[N:14](C(OC(C)(C)C)=O)[CH:9]([CH2:10][CH2:11]3)[CH2:8]2)=[CH:3][CH:2]=1.[ClH:22]>O1CCOCC1>[ClH:22].[ClH:22].[N:1]1[CH:6]=[CH:5][C:4]([CH:7]2[CH2:13][CH:12]3[NH:14][CH:9]([CH2:10][CH2:11]3)[CH2:8]2)=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67267778Tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane-8-carboxylate

Product 1

HCID 672677423-Pyridin-4-yl-8-azabicyclo[3.2.1]octane dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.76 g of tert-butyl 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane-8-carboxylate and 4 ml of a 4N solution of hydrochloric acid in dioxane are placed in a 10 ml round-bottomed flask. The reaction mixture is stirred for one and a half hours. The dioxane is evaporated off and 0.341 g of 3-pyridin-4-yl-8-azabicyclo[3.2.1]octane dihydrochloride is obtained.

Workup

  1. customThe dioxane is evaporated off

Sources & evidence

ORD record
ord-e3fa632933b54cd9a0623c90de3a695f
Source dataset
uspto-grants-2011_03
Patent number
US07897773B2

Reaction notes

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