反应详情

温度

90 °C

A mixture of NH4Cl (14.9 mmol) and iron powder (18.4 mmol) in H2O (5 mL) was stirred at 90° C. 2-bromo-4-methyl-5-nitropyridine (2.3 mmol) was added in portions. The mixture was stirred at 90° C. for 1 h and 15 min. The reaction was stopped and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated to yield the desired product.

1. stirringThe mixture was stirred at 90° C. for 1 h and 15 min
2. extractionextracted with EtOAc
3. dry with materialThe organic layer was dried (Na2SO4)
4. concentrationconcentrated