Ammonium Chloride → HCID 118235328, compound

HRID 59946Notes

Reaction equation

HRID 59946 reaction equation
[CH2:1]([C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][N:6]=[C:5]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:4]=1)[CH3:2].[NH4+].[Cl-]>O.[Fe]>[CH2:1]([C:3]1[CH:4]=[C:5]([S:12]([CH3:15])(=[O:14])=[O:13])[N:6]=[CH:7][C:8]=1[NH2:9])[CH3:2]

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 118235388HCID 118235388, compound

Product 1

HCID 118235328HCID 118235328, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 4-ethyl-2-methylsulfonyl-5-nitro-pyridine (4.1 mmol), NH4Cl (26.65 mmol) and iron powder (33 mmol) in H2O (10 mL) was stirred at 90° C. for 1 h. The reaction was stopped, filtered and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated to yield the desired product.

Workup

  1. filtrationfiltered
  2. extractionextracted with EtOAc
  3. dry with materialThe organic layer was dried (Na2SO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-409cfb22782f4394b19b3be5375b494e
Source dataset
uspto-grants-2016_09
Patent number
US09440929B2

Reaction notes

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