反应详情

A suspension of the Boc-protected amino phenylethanamine intermediate (0.22 mmol) in anhydrous DCM (2 mL) was treated with 4.0 M HCl in 1,4-dioxane (1.1 mmol, 5 eq), and the contents were stirred at room temperature. Dissolution occurred, followed by precipitation of a solid. After 3 hours, the solid was collected by filtration, washed with diethyl ether (10 mL) and dried under vacuum for 2 hours to afford B as a white or off-white solid (63-95%).

1. dissolutionDissolution
2. customfollowed by precipitation of a solid
3. filtrationthe solid was collected by filtration
4. washwashed with diethyl ether (10 mL)
5. customdried under vacuum for 2 hours