反应详情

A suspension of the Boc-protected amino phenylethanamine intermediate (38.61 mmol) in anhydrous MeOH (50 mL) was treated with 2.0 M HCl in diethyl ether (200 mmol, 5 eq), and the contents were stirred at room temperature. Dissolution occurred, followed by precipitation of a solid. After 3 hours, the solid was collected by filtration, washed with diethyl ether (100 mL) and dried under vacuum for 2 hours to afford B as a white or off-white solid (69-75%).

1. dissolutionDissolution
2. customfollowed by precipitation of a solid
3. filtrationthe solid was collected by filtration
4. washwashed with diethyl ether (100 mL)
5. customdried under vacuum for 2 hours